Co Q10 Benefits And
Cardiovascular Disease

Cardiovascular disease is a top killer among adults. It is such a serious condition that we are reminded in commercials about topics ranging from breakfast foods to prescription medicines. Unfortunately we are not often reminded of Co Q10 benefits in relation to cardiovascular disease. 

If you do not know what Co Q10 is you can return to the Co Q10 main page and get caught up.

What is Cardiovascular Disease?

Cardiovascular disease in its broadest definition refers to any disease that involves the heart and/or blood vessels. However, in its restricted sense it refers to conditions related to atherosclerosis, otherwise known as arterial disease. It is in this latter sense that we understand it for purposes of discussion on this page. 

In other words, we are concerned with the damage that occurs to our blood vessels because of atherosclerosis - hardening of the arteries. 

So much harm is done to our heart and arteries because of this horrible condition that it is imperative to dedicate a page to it in relation to CoQ10 benefits. 

By the time many heart conditions become evident it is usually the case that atherosclerosis is well advanced. Therefore it is important to do anything possible to prevent and reduce atherosclerosis damage.

This page is dedicated to CoQ10 benefits and atherosclerosis development.

What Causes Atherosclerosis?

Anyone who has considered atherosclerosis seriously is aware that LDL cholesterol is a prime concern. Unfortunately, most of us understand that to mean that we must keep our LDL cholesterol levels low. But this is only half the picture

You may be surprised to learn that it is actually the…

… oxidation of LDL that is the real menace in atherosclerosis development.

What does that mean practically? It means that keeping one’s LDL levels down may not be enough. Instead… 

We need to be concerned that our LDL does not oxidize. 

Want proof? Listen how a number of research papers on the topic of atherosclerosis and CoQ10 benefits begin. 

Oxidative modification of low-density lipoproteins (LDL) in artery walls is thought to represent an early event leading to the development of atherosclerosis.


Oxidation of low-density lipoprotein (LDL) lipid is implicated in atherogenesis.And…Intimal oxidation of LDL is considered an important early event in atherogenesis.

Many such studies begin with the well-founded belief that oxidation of LDL cholesterol is a major factor in the development of atherosclerosis. It makes sense, then, to counteract atherosclerosis development with strong antioxidants.

One of the strongest antioxidants available to counteract the development of atherosclerosis is Coenzyme Q10.

What follows are references to several studies on…

Here’s a question for you…

Are you sick and tired of just not feeling great?

Are there health issues – in addition to your heart health – that concern you? Like…

Anxiety? Or not sleeping well? Or joint pain? Or low energy? Or poor digestion? Or weight gain? Or stress? Why do so many people suffer from these symptoms and others? Those nagging health issues that seem so difficult to define.

Did you know that these health problems – as well as more serious chronic diseases – can be the result of …

  • Your body holding on to too many toxins?
  • And chronic inflammation?
  • And pH and blood sugar imbalance?
  • And your elimination organs not working well?
  • And poor nutrition?
  •  And foods that stress your system?

Many people have come to realize this and have made changes to recapture their health. We have a great – FREE – resource we want you to have. Simply click the link below.

Click here to learn how you can regain your health. 

CoQ10 Benefits and LDL Oxidation

Assuming LDL oxidation is an important problem for the development of cardiovascular disease helps us to see more clearly the significant implications of statements like… 

The antioxidant or free radical quenching properties of CoQ10 serve to greatly reduce oxidative damage to tissues as well as significantly inhibit the oxidation of LDL cholesterol (much more efficiently than vitamin E).

To read a great article from which these words were taken please click here. 

That is good news. It should be sufficient news to make many of us consider seriously adding COQ10 supplements to our heart health regimen. 

When we read a statement like the one above we might ask ourselves the question, "What about vitamin-E?" The statement above implies that vitamin-E inhibits LDL oxidation but not as well as CoQ10. Should we continue to take vitamin-E? Should we take CoQ10 instead?

This is where the research gets a little surprising.

There is ample evidence to suggest that vitamin-E can actually cause LDL oxidation. Yes, you read that correctly.

Vitamin-E can actually cause an event that leads to coronary heart disease.

That means that many of us have been taking vitamin-E for good heart health and all the time we may have been doing ourselves harm. So we can ask the question again, "Should we stop taking vitamin-E?" 

To answer that question let’s look at a couple of studies. They get a bit technical at points. But the struggle is well worth our efforts. 

One such study began with the following words. Don’t worry that it is a bit dense. Read it and then we will unpack it. 

Oxidation of low density lipoprotein (LDL) may be involved in the development of atherosclerosis. It has recently been shown that alpha-tocopherol (alpha-TOH) can act either as an antioxidant or prooxidant for isolated low density lipoprotein (LDL).

In the absence of an effective co-antioxidant, alpha-TOH is a prooxidant and this activity is evidently due to reaction of the alpha-tocopheroxyl radical (alpha-TO.) with the LDL's polyunsaturated lipids.

To read the rest of the study’s abstract please use the link below: 

Prevention of tocopherol-mediated peroxidation in ubiquinol-10-free human low density lipoprotein. 

We don’t have to understand everything the above statement is saying. Here are the important points.

  • Oxidation of LDL cholesterol may promote atherosclerosis and therefore coronary heart disease.
  • Research has shown that vitamin-E (alpha-tocopherol) can act as an antioxidant of LDL cholesterol.
  • But under certain conditions vitamin-E can actually cause LDL oxidation.
  • When another strong antioxidant is present it prevents vitamin-E from causing oxidation of LDL.

When vitamin-E functions as an antioxidant it reduces LDL oxidation and also atherosclerosis build-up. Obviously, then, when vitamin-E works as a prooxidant it has the opposite effect.

It has the potential to increase our likelihood of developing coronary heart disease.

The study went on to compare the oxidation levels of LDL in the presence of vitamin-E and other co-antioxidants. That is to say, they tested how effective vitamin-E worked as an antioxidant when other antioxidants were present. 

The bottom line is, vitamin-E works as an LDL antioxidant as long as it is not left to battle alone. It needs another strong antioxidant to refresh it. To see more on this let’s look at another study. 

This study is concerned more particularly with Co Q10 benefits. It begins much the same way as the previous one. 

Intimal oxidation of LDL is considered an important early event in atherogenesis, and certain antioxidants are antiatherogenic. Dietary coenrichment with vitamin E (VitE) plus ubiquinone-10 (CoQ(10), which is reduced during intestinal uptake to the antioxidant ubiquinol-10, CoQ(10)H(2)) protects, whereas enrichment with VitE alone can increase oxidizability of LDL lipid against ex vivo oxidation.To read more of this study use the link below: 

Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis. 

Here are the main points:

  • Oxidation of LDL can cause the development of atherosclerosis.
  • Some antioxidants can counteract atherosclerosis.
  • Vitamin-E plus CoQ10 protects against LDL oxidation and therefore atherosclerosis.
  • Vitamin-E by itself can actually increase LDL oxidation.

Vitamin-E does work as an antioxidant against LDL oxidation. But during the reaction vitamin-E changes. This change in vitamin-E structure makes it a prooxidant of LDL.

One of the many CoQ10 benefits is that it can refresh vitamin-E such that it once again functions as an antioxidant.

However, we do not want to assume that CoQ10’s main function is to refresh vitamin-E. On the contrary, CoQ10 is actually the stronger antioxidant. And there is no evidence that CoQ10 can ever become a prooxidant. 

Consider this statement from the same study…

Compared with control, plasma from CoQ(10) or VitE+CoQ(10) but not VitE-supplemented animals was more resistant to ex vivo lipid peroxidation induced by peroxyl radicals.

In other words, the animals that received CoQ10 supplements or a combination of CoQ10 and vitamin-E showed reduced LDL oxidation.Those receiving only vitamin-E did not show the same resistance to LDL oxidation. 

The study goes on to conclude…

Thus, in apoE-/- mice, VitE+CoQ(10) supplements are more antiatherogenic than CoQ(10) or VitE supplements alone.

That is, the mice that received both vitamin-E and CoQ10 supplements were better protected against atherosclerosis.

CoQ10 Benefits: Bringing It All Together

The combination of these studies, and many like them, demonstrate the following points:

  • Vitamin-E acts as an antioxidant helping to prevent the oxidation of LDL cholesterol.
  • Vitamin-E can become exhausted and changed in the fight against LDL oxidation.
  • This change can result in a substance that will actually promote LDL oxidation.
  • CoQ10 is a much stronger LDL antioxidant than vitamin-E.
  • CoQ10 also works to refresh or strengthen vitamin-E.
  • CoQ10 can prevent LDL oxidation but will never promote it.
  • The combination of CoQ10 and vitamin-E prevents LDL oxidation more effectively than either antioxidant alone.

Think about your heart health for a moment. We know that high LDL levels promote atherosclerosis and therefore coronary heart disease.

We now know that LDL oxidation is believed to be the real menace in atherosclerosis development.

CoQ10 (often in combination with vitamin-E) has been shown to reduce LDL oxidation. The Co Q10 benefits for coronary artery disease are two-fold:

  • Co Q10 helps prevent the oxidation of LDL cholesterol
  • Co Q10 refreshes vitamin-E keeping it from becoming and LDL prooxidant.

Doesn’t it make sense to seriously consider adding CoQ10 supplementation to your heart health efforts?

Make sure, however, you get your CoQ10 from a trusted source. Independent studies of supplement companies have revealed that some CoQ10 supplements contain 0% CoQ10. That’s not a good deal. 

Know the company behind your supplements. To help you in this please use the two links below. 

Return from Co Q10 Benefits and Cardiovascular Disease to the CoQ10 Main Page.

A Challenge For You!

People are making great improvements in their heart health.

How... are they doing it? By challenging themselves to change the way they eat. Really!

I have a challenge for you. It is my double dog dare.

Click here to learn about the 30_Day Challenge.

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